Biopharmaceutical Industry


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Endotoxin and Pyrogen Removal

Pyrogens are substances that induce a fever when injected into humans and animals and endotoxins are the single most important class of pyrogens. Depending on the states of aggregation, endotoxins can have individual molecular weights of 10-120kDa, or molecular weights as large as 1,000kDa. The choice of membrane filter will be based on size exclusion and charge interactions. Ultrafiltration technology has been proven to be effective for use throughout the biopharmaceutical industry by producing pyrogen and endotoxin-free solutions from dialysis fluids, tap water, and in the hemodialysis processes.

Benefits of membrane process

  1. Cost-effective method for optimal endotoxins removal
  2. Efficient flux rates and low operating pressures

Recommended membrane:

MT, ST or larger MWCO PES membrane, depending on the aggregation state of the endotoxins and the target rejection efficiency of the filter

Application Development Program

Learn more about Synder’s comprehensive custom application development program and wide variety of pilot systems available for testing. Here at Synder, we realize the importance of flexibility and responsiveness, which is why we created a comprehensive application development program to fulfill specific separation needs. We work closely with our customers to fully understand, design, and deliver both custom membranes and systems.

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At Synder Filtration, we take pride in providing technical expertise and personal collaboration with our customers. With our newly designed research & development laboratory and fleet of pilot systems, we are able to conduct a wide range of feasibility tests both in-house and on-site. … [read more]

Membrane Development Program
At Synder Filtration, we aim to provide quality products, technical expertise, and quick responsiveness. With our state-of-the-art laboratory, extensive array of pilot systems, and growing team of scientists and engineers, we are able to develop and customize innovative membranes to fit specific process separation needs and applications across all industries. We take pride in collaborating closely with our customers to ensure consistent… [read more]

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