Biopharmaceutical Industry


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Desalination and Concentration of Small Molecules from Fermentation Broths

The separation of small molecules from other salts may pose a challenge when using conventional methods such as evaporation or precipitation. Nanofiltration membrane technology holds vast potential in this field, to achieve the selective separation required for small, heat-sensitive molecules.

For example, in a feasibility test conducted at Synder HQ, biocides and fungicides with a small molecular weight range (<1,000Da) were needed to be derived from a fermentation broth. Synder’s NF membranes were showed high retention rates of the active compounds, while allowing salts and water to pass to the permeate stream via diafiltration. During the concentration and desalination process, there was also no detectable loss of active compounds in the permeate stream.

Benefits of membrane process

  1. Selective separation for small, heat-sensitive molecules
  2. Minimal loss of active compounds

Recommended membrane:


Application Development Program

Learn more about Synder’s comprehensive custom application development program and wide variety of pilot systems available for testing. Here at Synder, we realize the importance of flexibility and responsiveness, which is why we created a comprehensive application development program to fulfill specific separation needs. We work closely with our customers to fully understand, design, and deliver both custom membranes and systems.

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At Synder Filtration, we take pride in providing technical expertise and personal collaboration with our customers. With our newly designed research & development laboratory and fleet of pilot systems, we are able to conduct a wide range of feasibility tests both in-house and on-site. … [read more]

Membrane Development Program
At Synder Filtration, we aim to provide quality products, technical expertise, and quick responsiveness. With our state-of-the-art laboratory, extensive array of pilot systems, and growing team of scientists and engineers, we are able to develop and customize innovative membranes to fit specific process separation needs and applications across all industries. We take pride in collaborating closely with our customers to ensure consistent… [read more]

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