Concentration of Gibberellins (Pharmaceutical)

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Structure of Gibberellins

Background


Gibberellins (GA3) are the plant hormones that can be used to stimulate plant growth by influencing various developmental processes such as stem elongation, germination, and dormancy. The application of these hormones has led to significant increases in the yields of rice, wheat, corn, vegetable, and fruit harvests. An efficient and reliable method for concentrating gibberellins such as nanofiltration, is vital for pharmaceutical companies manufacturing these hormones.

Feed Solution, Membrane, Operating Conditions



Feed Solution  
Material Gibberellins, GA3 (C19H22O6)
Molecular Weight (Da) 346.37
Manufacturer Jiangsu Fengyuan Bioengineering Co.,Ltd.
Conductivity 4,000
Membrane  
Element NFX-3-8040HF
Spacer size (mil) 46
Number of Elements 20
Surface area per element (sq. ft) 295
Operating Conditions  
Element Inlet Pressure (PSI) 174-181
Pressure Drop per Element (PSI) 3-5
Temperature (°C) 30-32
pH 5.4-5.8

AD20 - Gibberellins - Image #2 Pilot Unit Used During The Study

Test Results & Conclusions



Results  
Experiment Duration (min) 200
Overall rejection 99%
Concentrate Volume (Gal) 8,453-9,774
Average Permeate Flux (GFD) 15
Permeate Conductivity (µs/cm) 570-810


The NFX membrane exhibited a 99% rejection of GA3 over the course of the 200 minute trial. The ultimate concentration factor ranged from 2.1-2.5 with an average permeate flux of 15 GFD. With this combination of rejection and flux, the NFX Nanofiltration offers excellent overall performance in this application.